🇵🇦 Panama City · Plate30 Guide

Best Restaurants in San Francisco, Panama City

7 hand-verified restaurants

San Francisco is a quieter neighbourhood than its name suggests — wide tree-lined streets, expat regulars, and a tight-knit restaurant scene that rewards those who know where to look. The seven spots here span omakase counters, convivial tapas bars, and Panama's best Afro-Caribbean smokehouse. Fewer tourists pass through here than Casco Viejo, which means the restaurants are cooking for locals — and that usually translates directly to quality.

Segundo Muelle
SAN FRANCISCO · Peruvian
$$

The Panama outpost of a celebrated Peruvian seafood house — bright ceviches, tiraditos and arroces in a breezy, contemporary room.

Athanasiou
SAN FRANCISCO · Greek Bakery & Café
$$

A Greek family bakery-café turning out artisan breads, pastries and Mediterranean plates — equally suited to morning coffee and a long, easy lunch.

Octo Smokehouse
SAN FRANCISCO · Afro-Caribbean Smokehouse
$$

Chef Archbold's love letter to Bocas del Toro — jerk-spiced, fire-driven, Afro-Caribbean soul in a San Francisco dining room. The ribs and oxtail are revelatory.

La Tapa del Coco
SAN FRANCISCO · Afro-Panamanian
$$

Panama's only dedicated Afro-Panamanian restaurant — rated 4.9★ with 1,045 reviews, ranked #22 in Panama City, and featured on Latin America's 50 Best. The One Pot Colonense and coconut-braised dishes carry centuries of Afro-Caribbean heritage onto the plate.

Espeziak
SAN FRANCISCO · Mediterranean · Basque
$$$

A perfect 5.0★ on TripAdvisor. Espeziak — Basque for 'spices' — is Panama City's most precise Mediterranean table, where Spanish pintxos, fire-roasted seafood and ingredient-driven cooking built around the finest European and local produce define a singular dining identity.

Umami Bodega
SAN FRANCISCO · Soul Food · Live Music
$$

Soul food and serious flavour in San Francisco — live jazz and reggae bands, DJ nights, Tuesday impromptu sessions, and the kind of neighbourhood bodega energy that keeps locals coming back.

Plate30 is Panama City's curated dining guide — bilingual, GPS-enabled, with open/close hours updated daily, a live concierge, and every restaurant personally vetted by a local. Free to use, no account required.

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